Inflammatory diseases of blood vessels PDF Book
This comprehensive reference emphasizes the dynamic events that occur in the maintenance and repair of blood vessels in health and abnormalities that may result from dysregulation of inflammatory and immune responses in disease. The editors have assembled authors and topics that bring new concepts about cell and molecular biology to the clinician to provide a better understanding of pathogenesis, the diagnostic process, and treatment. Recent insights into pathogenesis have dramatically influenced development of new therapies that target disease pathways.
Inflammatory Diseases of Blood Vessels discusses
- organ selectivity in varying forms of vascular disease
- mechanisms of arterial tissue injury
- functions of the extracellular matrix
- cytokine expression in vasculitic disorders
- diagnostic approaches to 1° and 2° vasculitis
- conventional therapies
- new targets for immunotherapy
- and more!
With contributions by 90 leading worldwide authorities in the field and providing over 4700 valuable references, drawings, photographs, micrographs, and tables, Inflammatory Diseases of Blood Vessels is an authoritative and essential resource for rheumatologists, pathologists, cardiologists, immunologists, allergists, nephrologists, pulmonologists, vascular and cardiothoracic surgeons, and trainees in these disciplines.
Description of Inflammatory diseases of blood vessels and editors review
Inflammation of the blood-vessel wall is the common feature of a broad spectrum of clinical entities known collectively as the vasculitic diseases. Vasculitis can occur as a secondary process in association with another disease or exposure, or as a primary idiopathic process. The primary vasculitides have individual patterns of vascular involvement and histopathological characteristics that influence their clinical features, severity, and management. Although the vasculitic diseases are uncommon, they invite the interest of a wide range of medical disciplines because of the variety of their manifestations and the diagnostic and therapeutic challenges they pose. In recent years, considerable progress has been made in understanding the vasculitic diseases. This has been due largely to the introduction of effective treatments for diseases that were once uniformly fatal, the conduct of structured clinical studies, and advances in immunology and molecular biology. Despite these achievements, the vasculitic diseases continue to be associated with morbidity and mortality from chronic organ damage, relapses, and the side effects of treatment. Investigations into the mechanisms of vascular inflammation may lead to a better comprehension of the pathogenesis of vasculitic diseases and to treatment that is more effective and less toxic. These areas of promising research, together with current knowledge about the vasculitic diseases, are extensively examined in Inflammatory Diseases of Blood Vessels. The book broadly reviews the science and clinical consequences of vascular inflammation. Although the vasculitic diseases are at its core, the book also includes several chapters on the contribution of immune cells and inflammatory pathways in atherosclerosis and acute coronary syndromes. By breaking down the traditional separation between noninflammatory and inflammatory vasculopathies, the editors offer an insightful, future-oriented view of a wide range of vascular diseases in which immunologic mechanisms may have an important role. The book has three sections. The first examines the immunopathologic mechanisms of vessel injury. The chapters in this section provide a comprehensive and useful resource for the immunologist and the clinician alike by exploring specific topics and illustrating key concepts with unambiguous diagrams. The clinical consequences of vascular inflammation, as viewed from the framework of the primary and secondary vasculitides, are reviewed in the second and third sections, respectively. The section on primary vasculitides begins with six chapters on the history of vasculitis, its epidemiologic characteristics, the approach to diagnosis, histopathological features, use of radiographic diagnostics, and arteriographic studies. These topics are an important introduction to the disease-specific chapters that follow. Each of the primary vasculitic diseases receives a detailed, excellent discussion. For several of the diseases, the pathogenesis and clinical aspects are discussed in separate chapters. Even with this separation, the chapters on pathophysiology consistently address the relation between in vitro findings and human disease, emphasizing the connection between laboratory and clinical science. The clinically focused chapters provide practical information on the features of these complex diseases at presentation and their diagnosis and treatment. In the final section of the book, the causes of secondary vasculitis receive thorough coverage. Although they are commonly encountered in clinical practice, the secondary vasculitides often receive less attention in published reviews. Such is not the case in this textbook, which has individual chapters devoted to vasculitis occurring in association with infections, medications, cancers, and specific connective-tissue diseases. In addition to its content, this textbook has a number of strengths. The editors, who are respected authorities on vasculitic disease, have assembled a team of experts to contribute to the book. They emphasize the analysis of primary data from key studies and provide thorough citations. Well-labeled figures are present throughout the book, including two sections containing color plates of histologic and clinical images. Inflammatory Diseases of Blood Vessels is an outstanding textbook not only for specialists but also for students, scientists, and clinicians in many disciplines. Readers of all constituencies will be well served by this book, which will undoubtedly remain a valuable reference for many years to come.
About the Author
The Author of this Book is Cornelia M Weyand and Gary S Hoffman who have written many other masterpieces in their lifetime. She is Currently a Professor at Stamford University.
Table of Contents
Inflammatory Diseases of Blood Vessels PDF Book has the following 3 main units along with many chapters
- Scientific Basis for Health and Diseases
- Primary Vasculitis
- Secondary Vasculitis
File Size: 127 MBs
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